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dc.contributor.authorKachuri, Linda
dc.contributor.authorSaarela, Olli
dc.contributor.authorBojesen, Stig Egil
dc.contributor.authorSmith, George Davey
dc.contributor.authorLiu, Geoffrey
dc.contributor.authorLandi, Maria Teresa
dc.contributor.authorCaporaso, Neil E.
dc.contributor.authorChristiani, David C.
dc.contributor.authorJohansson, Mattias
dc.contributor.authorPanico, Salvatore
dc.contributor.authorOvervad, Kim
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorVineis, Paolo
dc.contributor.authorScelo, Ghislaine
dc.contributor.authorZaridze, David
dc.contributor.authorWu, Xifeng
dc.contributor.authorAlbanes, Demetrius
dc.contributor.authorDiergaarde, Brenda
dc.contributor.authorLagiou, Pagona
dc.contributor.authorMacFarlane, Gary J.
dc.contributor.authorAldrich, Melinda C.
dc.contributor.authorTardón, Adonina
dc.contributor.authorRennert, Gad
dc.contributor.authorOlshan, Andrew F.
dc.contributor.authorWeissler, Mark C.
dc.contributor.authorChen, Chu
dc.contributor.authorGoodman, Gary E.
dc.contributor.authorDoherty, Jennifer A.
dc.contributor.authorNess, Andrew R.
dc.contributor.authorBickeböller, Heike
dc.contributor.authorWichmann, H.-Erich
dc.contributor.authorRisch, Angela
dc.contributor.authorField, John K.
dc.contributor.authorTeare, M. Dawn
dc.contributor.authorKiemeney, Lambertus A.
dc.contributor.authorvan der Heijden, Erik H.F.M.
dc.contributor.authorCarroll, June C.
dc.contributor.authorHaugen, Aage
dc.contributor.authorZienolddiny, Shanbeh
dc.contributor.authorSkaug, Vidar
dc.contributor.authorWünsch-Filho, Victor
dc.contributor.authorTajara, Eloiza H.
dc.contributor.authorMoysés, Raquel Ayoub
dc.contributor.authorNunes, Fabio Daumas
dc.contributor.authorLam, Stephen
dc.contributor.authorEluf-Neto, Jose
dc.contributor.authorLacko, Martin
dc.contributor.authorPeters, Wilbert H. M.
dc.contributor.authorLe Marchand, Loic
dc.contributor.authorDuell, Eric J.
dc.contributor.authorAndrew, Angeline S.
dc.contributor.authorFranceschi, Silvia
dc.contributor.authorSchabath, Matthew B.
dc.contributor.authorManjer, Jonas
dc.contributor.authorArnold, Susanne
dc.contributor.authorLazarus, Philip
dc.contributor.authorMukeriya, Anush
dc.contributor.authorSwiatkowska, Beata
dc.contributor.authorJanout, Vladimir
dc.contributor.authorHolcatova, Ivana
dc.contributor.authorStojsic, Jelena
dc.contributor.authorMates, Dana
dc.contributor.authorLissowska, Jolanta
dc.contributor.authorBoccia, Stefania
dc.contributor.authorLesseur, Corina
dc.contributor.authorZong, Xuchen
dc.contributor.authorMckay, James D.
dc.contributor.authorBrennan, Paul
dc.contributor.authorAmos, Christopher I.
dc.contributor.authorHung, Rayjean J.
dc.date.accessioned2019-06-05T23:47:41Z
dc.date.available2019-06-05T23:47:41Z
dc.date.issued2019
dc.identifier124841705
dc.identifieraeb9b2a6-befc-4535-87be-14b7a0bb5c81
dc.identifier85068783172
dc.identifier000486642400015
dc.identifier.citationKachuri , L , Saarela , O , Bojesen , S E , Smith , G D , Liu , G , Landi , M T , Caporaso , N E , Christiani , D C , Johansson , M , Panico , S , Overvad , K , Trichopoulou , A , Vineis , P , Scelo , G , Zaridze , D , Wu , X , Albanes , D , Diergaarde , B , Lagiou , P , MacFarlane , G J , Aldrich , M C , Tardón , A , Rennert , G , Olshan , A F , Weissler , M C , Chen , C , Goodman , G E , Doherty , J A , Ness , A R , Bickeböller , H , Wichmann , H -E , Risch , A , Field , J K , Teare , M D , Kiemeney , L A , van der Heijden , E H F M , Carroll , J C , Haugen , A , Zienolddiny , S , Skaug , V , Wünsch-Filho , V , Tajara , E H , Moysés , R A , Nunes , F D , Lam , S , Eluf-Neto , J , Lacko , M , Peters , W H M , Le Marchand , L , Duell , E J , Andrew , A S , Franceschi , S , Schabath , M B , Manjer , J , Arnold , S , Lazarus , P , Mukeriya , A , Swiatkowska , B , Janout , V , Holcatova , I , Stojsic , J , Mates , D , Lissowska , J , Boccia , S , Lesseur , C , Zong , X , Mckay , J D , Brennan , P , Amos , C I & Hung , R J 2019 , ' Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers ' , International Journal of Epidemiology , vol. 48 , no. 3 , pp. 751-766 . https://doi.org/10.1093/ije/dyy140en
dc.identifier.issn0300-5771
dc.identifier.otherMendeley: cc91b53b-d7fc-3950-8961-713e60046f53
dc.identifier.otherORCID: /0000-0003-2322-3314/work/72631717
dc.identifier.urihttp://hdl.handle.net/2164/12364
dc.descriptionL.K. is a fellow in the Canadian Institutes of Health Research (CIHR) Strategic Training in Advanced Genetic Epidemiology (STAGE) programme and is supported by the CIHR Doctoral Research Award from the Frederick Banting and Charles Best Canada Graduate Scholarships (GSD-137441). Transdisciplinary Research for Cancer in Lung (TRICL) of the International Lung Cancer Consortium (ILCCO) was supported by the National Institutes of Health (U19-CA148127, CA148127S1). Genotyping for the TRICL-ILCCO OncoArray was supported by in-kind genotyping at Centre for Inherited Disease Research (CIDR) (26820120008i-0–6800068-1). Genotyping for the Head and Neck Cancer OncoArray performed at CIDR was funded by the US National Institute of Dental and Craniofacial Research (NIDCR) grant 1X01HG007780–0. CAPUA study was supported by FIS-FEDER/Spain grant numbers FIS-01/310, FIS-PI03–0365 and FIS-07-BI060604, FICYT/Asturias grant numbers FICYT PB02–67 and FICYT IB09–133, and the University Institute of Oncology (IUOPA), of the University of Oviedo and the Ciber de Epidemiologia y Salud Pública. CIBERESP, SPAIN. The work performed in the CARET study was supported by the National Institute of Health (NIH)/National Cancer Institute (NCI): UM1 CA167462 (PI: Goodman), National Institute of Health UO1-CA6367307 (PIs Omen, Goodman); National Institute of Health R01 CA111703 (PI Chen), National Institute of Health 5R01 CA151989 (PI Doherty). The Liverpool Lung Project is supported by the Roy Castle Lung Cancer Foundation. The Harvard Lung Cancer Study was supported by the NIH (National Cancer Institute) grants CA092824, CA090578 and CA074386. The Multiethnic Cohort Study was partially supported by NIH Grants CA164973, CA033619, CA63464 and CA148127. The work performed in MSH-PMH study was supported by the Canadian Cancer Society Research Institute (020214), Ontario Institute of Cancer and Cancer Care Ontario Chair Award to R.J.H. and G.L. and the Alan Brown Chair and Lusi Wong Programs at the Princess Margaret Hospital Foundation. The Norway study was supported by Norwegian Cancer Society, Norwegian Research Council. The work in TLC study has been supported in part the James & Esther King Biomedical Research Program (09KN-15), National Institutes of Health Specialized Programs of Research Excellence (SPORE) Grant (P50 CA119997) and by a Cancer Center Support Grant (CCSG) at the H. Lee Moffitt Cancer Center and Research Institute, an NCI designated Comprehensive Cancer Center (grant number P30-CA76292). The dataset(s) used for the analyses described were obtained from Vanderbilt University Medical Center’s BioVU, which is supported by institutional funding and by the Vanderbilt CTSA grant UL1 TR000445 from NCATS/NIH. Dr Melinda Aldrich is supported by the by NIH/National Cancer Institute 5K07CA172294. The Copenhagen General Population Study (CGPS) was supported by the Chief Physician Johan Boserup and Lise Boserup Fund, the Danish Medical Research Council and Herlev Hospital. The NELCS study: Grant Number P20RR018787 from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH). Kentucky Lung Cancer Research Initiative (KLCRI) was supported by the Department of Defense (Congressionally Directed Medical Research Program, U.S. Army Medical Research and Materiel Command Program) under award number: 10153006 (W81XWH-11–1-0781). Views and opinions of, and endorsements by the author(s) do not reflect those of the US Army or the Department of Defense. This research was also supported by unrestricted infrastructure funds from the UK Center for Clinical and Translational Science, NIH grant UL1TR000117 and Markey Cancer Center NCI Cancer Center Support Grant (P30 CA177558) Shared Resource Facilities: Cancer Research Informatics, Biospecimen and Tissue Procurement, and Biostatistics and Bioinformatics. The research undertaken by M.D.T., L.V.W. and M.S.A. was partly funded by the National Institute for Health Research (NIHR). The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. M.D.T. holds a Medical Research Council Senior Clinical Fellowship (G0902313). The Tampa study was funded by Public Health Service grants P01-CA68384 and R01-DE13158 from the National Institutes of Health. The University of Pittsburgh head and neck cancer case–control study is supported by US National Institutes of Health grants P50 CA097190 and P30 CA047904. The Carolina Head and Neck Cancer Study (CHANCE) was supported by the National Cancer Institute (R01CA90731). The Head and Neck Genome Project (GENCAPO) was supported by the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP; grants 04/12054–9 and 10/51168–0). The authors thank all the members of the GENCAPO team. This publication presents data from the Head and Neck 5000 study. The study was a component of independent research funded by the National Institute for Health Research (NIHR) under its Programme Grants for Applied Research scheme (RP-PG-0707–10034). The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. Human papillomavirus (HPV) serology was supported by a Cancer Research UK Programme Grant, the Integrative Cancer Epidemiology Programme (grant number: C18281/A19169). The Alcohol-Related Cancers and Genetic Susceptibility Study in Europe (ARCAGE) was funded by the European Commission’s fifth framework programme (QLK1– 2001-00182), the Italian Association for Cancer Research, Compagnia di San Paolo/FIRMS, Region Piemonte and Padova University (CPDA057222). The Rome Study was supported by the Associazione Italiana per la Ricerca sul Cancro (AIRC) awards IG 2011 10491 and IG 2013 14220 to S.B. and by Fondazione Veronesi to S.B. The IARC Latin American study was funded by the European Commission INCO-DC programme (IC18-CT97–0222), with additional funding from Fondo para la Investigación Científica y Tecnológica (Argentina) and the Fundação de Amparo à Pesquisa do Estado de São Paulo (01/01768–2). The IARC Central Europe study was supported by the European Commission’s INCO-COPERNICUS Program (IC15-CT98–0332), US NIH/National Cancer Institute grant CA92039 and World Cancer Research Foundation grant WCRF 99A28. The IARC Oral Cancer Multicenter study was funded by grant S06 96 202489 05F02 from Europe against Cancer; grants FIS 97/0024, FIS 97/0662 and BAE 01/5013 from Fondo de Investigaciones Sanitarias, Spain; the UICC Yamagiwa-Yoshida Memorial International Cancer Study; the National Cancer Institute of Canada; Associazione Italiana per la Ricerca sul Cancro; and the Pan-American Health Organization. Coordination of the EPIC study is financially supported by the European Commission (DG SANCO) and the International Agency for Research on Cancer.en
dc.format.extent16
dc.format.extent1038120
dc.language.isoeng
dc.relation.ispartofInternational Journal of Epidemiologyen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectlung canceren
dc.subjecttelomere lengthen
dc.subjectchromosome 5p15.33en
dc.subjectMendelian randomizationen
dc.subjectmediation analysisen
dc.subjectTERTen
dc.subjectMendelian Randomizationen
dc.subjectMETAANALYSISen
dc.subjectSUSCEPTIBILITY LOCIen
dc.subjectEXTENSIONen
dc.subjectGENETIC-VARIANTSen
dc.subjectIDENTIFICATIONen
dc.subjectCHALLENGESen
dc.subjectNEVER SMOKERSen
dc.subjectDYSFUNCTIONen
dc.subjectEPIDEMIOLOGYen
dc.subjectGENOME-WIDE ASSOCIATIONen
dc.subjectR Medicine (General)en
dc.subjectEpidemiologyen
dc.subjectMedical Research Council (MRC)en
dc.subjectG0902313en
dc.subjectCancer Research UKen
dc.subjectC18281/A19169en
dc.subjectNational Institute for Health Research (NIHR)en
dc.subjectRP-PG-0707-10034en
dc.subjectEuropean Commissionen
dc.subjectQLK1- 2001-00182en
dc.subjectIC18-CT97-0222en
dc.subjectIC15-CT98-0332en
dc.subjectSupplementary Dataen
dc.subject.lccR1en
dc.titleMendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancersen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Other Applied Health Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Epidemiology Groupen
dc.contributor.institutionUniversity of Aberdeen.Institute of Applied Health Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Centre for Arthritis and Musculoskeletal Health (ACAMH)en
dc.description.statusPeer revieweden
dc.identifier.doi10.1093/ije/dyy140
dc.date.embargoedUntil2019-07-28
dc.identifier.urlhttp://www.mendeley.com/research/mendelian-randomization-mediation-analysis-leukocyte-telomere-length-risk-lung-head-neck-cancersen
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85068783172&partnerID=8YFLogxKen


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