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Selective anticancer activity of a hexapeptide with sequence homology to a non-kinase domain of Cyclin Dependent Kinase 4

dc.contributor.authorWarenius, Hilmar M.
dc.contributor.authorKilburn, Jeremy D
dc.contributor.authorEssex, Jon W.
dc.contributor.authorMaurer, Richard I.
dc.contributor.authorBlaydes, Jeremy P.
dc.contributor.authorAgarwala, Usha
dc.contributor.authorSeabra, Laurence A.
dc.date.accessioned2019-04-22T15:00:06Z
dc.date.available2019-04-22T15:00:06Z
dc.date.issued2011-06-13
dc.identifier69013807
dc.identifier5126eadb-b0d5-41ad-bfb7-db9eb69f65b5
dc.identifier000292200100001
dc.identifier79958254609
dc.identifier.citationWarenius , H M , Kilburn , J D , Essex , J W , Maurer , R I , Blaydes , J P , Agarwala , U & Seabra , L A 2011 , ' Selective anticancer activity of a hexapeptide with sequence homology to a non-kinase domain of Cyclin Dependent Kinase 4 ' , Molecular Cancer , vol. 10 , 72 . https://doi.org/10.1186/1476-4598-10-72en
dc.identifier.issn1476-4598
dc.identifier.urihttp://hdl.handle.net/2164/12198
dc.descriptionWe are grateful to Mikhail Lomosonov for Western blotting of Cdk1/Cdk4 in RT112 cells, Bill Primrose (Theryte Ltd) for designing THR79, Kyla Grimshaw (Horizon Discovery Services, 260 Cambridge Science Park, Milton Road, Cambridge, CB4 0WE) for some of the clonogenic assays and photomicrography, Kyla Grimshaw and John Goodall for carrying out sulphorhodamine, Alamar Blue, Cell Titre-Glo and autophagy assays and Amanda Howarth for data analysis and preparation of figures. This work was supported by the Cancer and Polio Research Fund, Hoylake, Wirral, UK and Theryte Ltd., William Russell House, The Square, Lightwater, Surrey, GU18 5SS, UK.en
dc.format.extent16
dc.format.extent6243952
dc.language.isoeng
dc.relation.ispartofMolecular Canceren
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectCdk4en
dc.subjectnon-kinaseen
dc.subjectproteomicen
dc.subjectPRGPRPen
dc.subjectprogrammed cell deathen
dc.subjectselective anticanceren
dc.subjectbroad spectrumen
dc.subjectSKIN TUMOR-DEVELOPMENTen
dc.subjectHUMAN CANCER-CELLSen
dc.subjectIN-VITROen
dc.subjectKERATINOCYTE PROLIFERATIONen
dc.subjectCDK4en
dc.subjectPROTEINen
dc.subjectASSAYen
dc.subjectCOEXPRESSIONen
dc.subjectACTIVATIONen
dc.subjectPREDICTIONen
dc.subjectR Medicineen
dc.subject.lccRen
dc.titleSelective anticancer activity of a hexapeptide with sequence homology to a non-kinase domain of Cyclin Dependent Kinase 4en
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Chemistryen
dc.contributor.institutionUniversity of Aberdeen.Senior Vice Principalsen
dc.description.statusPeer revieweden
dc.identifier.doi10.1186/1476-4598-10-72
dc.identifier.vol10en


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