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Molecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes

dc.contributor.authorChakera, Ali J.
dc.contributor.authorHurst, Paul S.
dc.contributor.authorSpyer, Gill
dc.contributor.authorOgunnowo-Bada, Emmanuel O.
dc.contributor.authorMarsh, William J.
dc.contributor.authorRiches, Christine H.
dc.contributor.authorYueh, Chen-Yu
dc.contributor.authorMarkkula, S.Pauliina
dc.contributor.authorDalley, Jeffrey W.
dc.contributor.authorCox, Roger D.
dc.contributor.authorMacdonald, Ian A.
dc.contributor.authorAmiel, Stephanie A.
dc.contributor.authorMacLeod, Kenneth M.
dc.contributor.authorHeisler, Lora K.
dc.contributor.authorHattersley, Andrew T.
dc.contributor.authorEvans, Mark L.
dc.date.accessioned2018-11-02T16:00:06Z
dc.date.available2018-11-02T16:00:06Z
dc.date.issued2018-11
dc.identifier130356339
dc.identifier3c334a21-8b05-479a-a6fe-e1b362f721d3
dc.identifier30146176
dc.identifier85052135529
dc.identifier000447687500002
dc.identifier.citationChakera , A J , Hurst , P S , Spyer , G , Ogunnowo-Bada , E O , Marsh , W J , Riches , C H , Yueh , C-Y , Markkula , S P , Dalley , J W , Cox , R D , Macdonald , I A , Amiel , S A , MacLeod , K M , Heisler , L K , Hattersley , A T & Evans , M L 2018 , ' Molecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes ' , Molecular Metabolism , vol. 17 , pp. 17-27 . https://doi.org/10.1016/j.molmet.2018.08.001en
dc.identifier.issn2212-8778
dc.identifier.otherRIS: urn:6854C5EEC84F4100B3AC4E9B6E33C33D
dc.identifier.urihttp://hdl.handle.net/2164/11381
dc.format.extent11
dc.format.extent1465234
dc.language.isoeng
dc.relation.ispartofMolecular Metabolismen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectGlucokinaseen
dc.subjectHypoglycemiaen
dc.subjectCounter-regulationen
dc.subjectGlucagonen
dc.subjectEpinephrineen
dc.subjectInsulin clampen
dc.subjectMaturity Onset Diabetes of Young (MODY)en
dc.subjectβ-cellsen
dc.subjectARCen
dc.subjectArcuate nucleusen
dc.subjectGEen
dc.subjectGlucose exciteden
dc.subjectGIen
dc.subjectGlucose inhibiteden
dc.subjectGCKen
dc.subjectHOMen
dc.subjectHomozygousen
dc.subjectHETen
dc.subjectHeterozygousen
dc.subjectSTZen
dc.subjectStreptozotocinen
dc.subjectVMNen
dc.subjectVentromedial hypothalamusen
dc.subjectWTen
dc.subjectWild typeen
dc.subjectR Medicine (General)en
dc.subject.lccR1en
dc.titleMolecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetesen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.University of Aberdeenen
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.description.statusPeer revieweden
dc.identifier.doi10.1016/j.molmet.2018.08.001
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S2212877818307506en


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