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Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons

dc.contributor.authorBurke, Luke K.
dc.contributor.authorDoslikova, Barbora
dc.contributor.authorD'Agostino, Giuseppe
dc.contributor.authorGreenwald-Yarnell, Megan
dc.contributor.authorGeorgescu, Teodora
dc.contributor.authorChianese, Raffaella
dc.contributor.authorMartinez de Morentin, Pablo B.
dc.contributor.authorOgunnowo-Bada, Emmanuel
dc.contributor.authorCansell, Celine
dc.contributor.authorValencia-Torres, Lourdes
dc.contributor.authorGarfield, Alastair S.
dc.contributor.authorApergis-Schoute, John
dc.contributor.authorLam, Daniel D.
dc.contributor.authorSpeakman, John R.
dc.contributor.authorRubinstein, Marcelo
dc.contributor.authorLow, Malcolm J.
dc.contributor.authorRochford, Justin J.
dc.contributor.authorMyers, Martin G.
dc.contributor.authorEvans, Mark L.
dc.contributor.authorHeisler, Lora K.
dc.date.accessioned2016-03-18T16:00:09Z
dc.date.available2016-03-18T16:00:09Z
dc.date.issued2016-03
dc.identifier63896559
dc.identifiere61be285-b8bd-46b3-ace7-c1a92c70e26d
dc.identifier84959140900
dc.identifier26977396
dc.identifier84959140900
dc.identifier.citationBurke , L K , Doslikova , B , D'Agostino , G , Greenwald-Yarnell , M , Georgescu , T , Chianese , R , Martinez de Morentin , P B , Ogunnowo-Bada , E , Cansell , C , Valencia-Torres , L , Garfield , A S , Apergis-Schoute , J , Lam , D D , Speakman , J R , Rubinstein , M , Low , M J , Rochford , J J , Myers , M G , Evans , M L & Heisler , L K 2016 , ' Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons ' , Molecular Metabolism , vol. 5 , no. 3 , pp. 245-252 . https://doi.org/10.1016/j.molmet.2016.01.005en
dc.identifier.issn2212-8778
dc.identifier.otherORCID: /0000-0002-5020-4939/work/53729085
dc.identifier.urihttp://hdl.handle.net/2164/5703
dc.descriptionAcknowledgments Work was supported by the Wellcome Trust (WT098012; WT081713) and Biotechnology and Biological Sciences Research Council (BB/K001418/1) to LKH, Wellcome Trust (093566/Z/10/A) to LKB/LKH, the Diabetes UK (13/0004680) to MLE, the Genomics/Transcriptomics core, Disease Model Core, Bespoke Mouse Models, Imaging, Proteomics Wellcome Trust Strategic Award [100574/Z/12/Z] and Genomics/Transcriptomics Core Facilities, Disease Model Core, CBAL MRC Metabolic Diseases Unit [MRC_MC_UU_12012/5] to LKH, MLE, BD and LKB, the Neuroscience Graduate Program, University of Michigan to MG-Y, the National Institute of Health (DK066604) to MJL and (DK068400) to MJL and MR, and National Institute of Health (DK056731) and the Marilyn H. Vincent Foundation to MGM. The University of Michigan Transgenic Core facility is partially supported by the NIH-funded University of Michigan Center for Gastrointestinal Research (DK034933). The authors would like to thank Dr Samuel Virtue for technical training in BAT lipid accumulation quantification.en
dc.format.extent8
dc.format.extent1797269
dc.language.isoeng
dc.relation.ispartofMolecular Metabolismen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject5-HT2c receptoren
dc.subjectBrown adipose tissueen
dc.subjectEnergy expenditureen
dc.subjectHyperinsulinemiaen
dc.subjectHypothalamusen
dc.subjectObesityen
dc.subjectPro-opiomelanocortin (Pomc)en
dc.subjectSexual dimorphismen
dc.subjectR Medicineen
dc.subjectQH301 Biologyen
dc.subjectCell Biologyen
dc.subjectMolecular Biologyen
dc.subjectWellcome Trusten
dc.subjectWT098012en
dc.subjectWT081713en
dc.subject093566/Z/10/Aen
dc.subject100574/Z/12/Zen
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBB/K001418/1en
dc.subjectMedical Research Council (MRC)en
dc.subjectMRC_MC_UU_12012/5en
dc.subject.lccRen
dc.subject.lccQH301en
dc.titleSex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neuronsen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.contributor.institutionUniversity of Aberdeen.Institute of Applied Health Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Biological Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Environment and Food Securityen
dc.contributor.institutionUniversity of Aberdeen.Energetics Research Groupen
dc.description.statusPeer revieweden
dc.identifier.doi10.1016/j.molmet.2016.01.005
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84959140900&partnerID=8YFLogxKen
dc.identifier.vol5en
dc.identifier.iss3en


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