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CARD9+ microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment

dc.contributor.authorDrummond, Rebecca A.
dc.contributor.authorSwamydas, Muthulekha
dc.contributor.authorOikonomou, Vasileios
dc.contributor.authorZhai, Bing
dc.contributor.authorDambuza, Ivy
dc.contributor.authorSchaefer, Brian C.
dc.contributor.authorBohrer, Andrea C.
dc.contributor.authorMayer-Barber, Katrin D.
dc.contributor.authorLira, Sergio A.
dc.contributor.authorIwakura, Yoichiro
dc.contributor.authorFiller, Scott G.
dc.contributor.authorBrown, Gordon D.
dc.contributor.authorHube, Bernhard
dc.contributor.authorNaglik, Julian R.
dc.contributor.authorHohl, Tobias M.
dc.contributor.authorLionakis, Michail S.
dc.date.accessioned2023-11-01T00:11:38Z
dc.date.available2023-11-01T00:11:38Z
dc.date.issued2019-05
dc.identifier141992305
dc.identifier3bc2fc05-44e0-4652-8032-9bf3ec1a7030
dc.identifier30996332
dc.identifier85064541511
dc.identifier000465084800013
dc.identifier.citationDrummond , R A , Swamydas , M , Oikonomou , V , Zhai , B , Dambuza , I , Schaefer , B C , Bohrer , A C , Mayer-Barber , K D , Lira , S A , Iwakura , Y , Filler , S G , Brown , G D , Hube , B , Naglik , J R , Hohl , T M & Lionakis , M S 2019 , ' CARD9 + microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment ' , Nature Immunology , vol. 20 , pp. 559-570 . https://doi.org/10.1038/s41590-019-0377-2en
dc.identifier.issn1529-2908
dc.identifier.otherMendeley: fcdb0b38-bcc1-358f-9aba-475b101f25bb
dc.identifier.urihttp://aura-test.abdn.ac.uk/handle/2164/19884
dc.descriptionThis work was supported by the Intramural Research Program of the National Institute of Allergy and Infectious Disease, National Institutes of Health, as well as NIH grants awarded to TMH (R01 093808), SGF (R01AI124566) and SRL (R01CA161373). Additional funding was provided by the Burroughs Wellcome Fund (awarded to TMH), the Wellcome Trust (102705, 097377; awarded to GDB), the MRC Centre for Medical Mycology and the University of Aberdeen (MR/N006364/1; awarded to GDB). The authors additionally thank Celeste Huaman for care and screening of the Malt1 793 -/- mice.en
dc.format.extent12
dc.format.extent5254776
dc.language.isoeng
dc.relation.ispartofNature Immunologyen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectAnimalsen
dc.subjectBrain/immunologyen
dc.subjectCARD Signaling Adaptor Proteins/geneticsen
dc.subjectCandida albicans/immunologyen
dc.subjectCandidiasis/geneticsen
dc.subjectChemokine CXCL1/geneticsen
dc.subjectCytokines/geneticsen
dc.subjectHost-Pathogen Interactions/immunologyen
dc.subjectInflammasomes/geneticsen
dc.subjectInterleukin-1beta/geneticsen
dc.subjectMice, Knockouten
dc.subjectMice, Transgenicen
dc.subjectMicroglia/immunologyen
dc.subjectNeutrophil Infiltration/geneticsen
dc.subjectNeutrophils/immunologyen
dc.subjectACTIVATIONen
dc.subjectSUSCEPTIBILITYen
dc.subjectASPARTYL PROTEINASESen
dc.subjectCENTRAL-NERVOUS-SYSTEMen
dc.subjectINFLAMMATORY MONOCYTESen
dc.subjectASTROCYTESen
dc.subjectDEFICIENCYen
dc.subjectHOST PROTECTIONen
dc.subjectFUNGAL-INFECTIONSen
dc.subjectCELLen
dc.subjectR Medicine (General)en
dc.subjectImmunology and Allergyen
dc.subjectImmunologyen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/N006364/1en
dc.subjectWellcome Trusten
dc.subject102705en
dc.subject097377en
dc.subjectSupplementary Dataen
dc.subject.lccR1en
dc.titleCARD9+ microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitmenten
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.MRC Centre for Medical Mycologyen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.description.statusPeer revieweden
dc.identifier.doi10.1038/s41590-019-0377-2
dc.date.embargoedUntil2019-10-17
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85064541511&partnerID=8YFLogxKen
dc.identifier.urlhttp://www.mendeley.com/research/card9-microglia-promote-antifungal-immunity-via-il1%CE%B2-cxcl1mediated-neutrophil-recruitmenten
dc.identifier.vol20en


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