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Metastatic-niche labelling reveals parenchymal cells with stem features

dc.contributor.authorOmbrato, Luigi
dc.contributor.authorNolan, Emma
dc.contributor.authorKurelac, Ivana
dc.contributor.authorMavousian, Antranik
dc.contributor.authorBridgeman, Victoria Louise
dc.contributor.authorHeinze, Ivonne
dc.contributor.authorChakravarty, Probir
dc.contributor.authorHorswell, Stuart
dc.contributor.authorGonzalez-Gualda, Estela
dc.contributor.authorMatacchione, Giulia
dc.contributor.authorWeston, Anne
dc.contributor.authorKirkpatrick, Joanna
dc.contributor.authorHusain, Ehab
dc.contributor.authorSpeirs, Valerie
dc.contributor.authorCollinson, Lucy
dc.contributor.authorOri, Alessandro
dc.contributor.authorLee, Joo-Hyeon
dc.contributor.authorMalanchi, Ilaria
dc.date.accessioned2020-02-28T00:02:46Z
dc.date.available2020-02-28T00:02:46Z
dc.date.issued2019-08-29
dc.identifier147243651
dc.identifier31d70c05-2626-4367-a891-6b56e3dd21a8
dc.identifier31462798
dc.identifier85071632233
dc.identifier000483405500043
dc.identifier85075027410
dc.identifier.citationOmbrato , L , Nolan , E , Kurelac , I , Mavousian , A , Bridgeman , V L , Heinze , I , Chakravarty , P , Horswell , S , Gonzalez-Gualda , E , Matacchione , G , Weston , A , Kirkpatrick , J , Husain , E , Speirs , V , Collinson , L , Ori , A , Lee , J-H & Malanchi , I 2019 , ' Metastatic-niche labelling reveals parenchymal cells with stem features ' , Nature , vol. 572 , no. 7771 , pp. 603-608 . https://doi.org/10.1038/s41586-019-1487-6 , https://doi.org/10.1038/s41586-019-1697-yen
dc.identifier.issn0028-0836
dc.identifier.otherMendeley: ebee40c3-4a23-3afe-8347-5d7af4351c8c
dc.identifier.otherORCID: /0000-0002-0602-4666/work/72631206
dc.identifier.urihttps://hdl.handle.net/2164/13754
dc.descriptionWe thank E. Sahai, P. Scaffidi (The Francis Crick Institute) and V. Sanz-Moreno (Barts Cancer Institute) for scientific discussions, critical reading of the manuscript and sharing cell lines and mouse strains; M. Izquierdo (CSIC, Madrid) for sharing the CD63–GFP plasmid; E. Nye and the pathologists G. Stamp and E. Herbert from the Experimental Histopathology Unit at the Francis Crick Institute for histological processing and analysis support; J. Bee from the Biological Resources Unit at the Francis Crick Institute for technical support with mice and mouse tissues; R. Goldstone and A. Edwards from the Advanced Sequencing Facility at the Francis Crick Institute for technical support; M. Llorian-Sopena from the Bioinformatics and Biostatistics Unit at the Francis Crick Institute for helping with the RNA sequencing analysis; the Flow Cytometry Unit at the Francis Crick Institute, particularly S. Purewal and J. Cerveira, for invaluable technical help; the Cell Services Unit at the Francis Crick Institute; C. Moore (The Francis Crick Institute) for intra-tracheal injections; and I. Pshenichnaya, P. Humphreys, S. McCallum and Cambridge Stem Cell Institute core facilities for technical assistance. We acknowledge support from the FLI Core Facility Proteomics, which is a member of the Leibniz Association and is financially supported by the Federal Government of Germany and the State of Thuringia. This work was supported by the Francis Crick Institute, which receives its core funding from Cancer Research UK (FC001112), the UK Medical Research Council (FC001112), and the Wellcome Trust (FC001112) and the European Research Council grant (ERC CoG-H2020-725492); and by the Wellcome Trust—MRC Stem Cell Institute, which receives funding from the Sir Henry Dale Fellowship from Wellcome, the Royal Society (107633/Z/15/Z) and the European Research Council Starting Grant (679411). Author Correction: Metastatic-niche labelling reveals parenchymal cells with stem features (Nature, (2019), 572, 7771, (603-608), 10.1038/s41586-019-1487-6) Luigi Ombrato, Emma Nolan, Ivana Kurelac, Antranik Mavousian, Victoria Louise Bridgeman, Ivonne Heinze, Probir Chakravarty, Stuart Horswell, Estela Gonzalez-Gualda, Giulia Matacchione, Anne Weston, Joanna Kirkpatrick, Ehab Husain, Valerie Speirs, Lucy Collinson, Alessandro Ori, Joo Hyeon Lee, Ilaria Malanchi, 2019, vol. 575, issue 7784, p. E8. Nature http://dx.doi.org/10.1038/s41586-019-1697-yen
dc.format.extent6
dc.format.extent3944826
dc.language.isoeng
dc.relation.ispartofNatureen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectCancer microenvironmenten
dc.subjectMetastasisen
dc.subjectALVEOLARen
dc.subjectLUNGen
dc.subjectACTIVATIONen
dc.subjectNEUTROPHILSen
dc.subjectMICEen
dc.subjectMODELen
dc.subjectEXPRESSIONen
dc.subjectR Medicineen
dc.subjectMedical Research Council (MRC)en
dc.subjectFC001112en
dc.subjectEuropean Research Councilen
dc.subjectCoG-H2020-725492en
dc.subject679411en
dc.subjectWellcome Trusten
dc.subjectFC001112en
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleMetastatic-niche labelling reveals parenchymal cells with stem featuresen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.description.statusPeer revieweden
dc.identifier.doi10.1038/s41586-019-1487-6
dc.date.embargoedUntil2020-02-28
dc.identifier.urlhttp://www.nature.com/articles/s41586-019-1487-6en
dc.identifier.urlhttp://www.mendeley.com/research/metastaticniche-labelling-reveals-parenchymal-cells-stem-featuresen


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